hSTING

Background : C57BL/6Smoc

Catalog : NM-HU-190036

Strain Name : C57BL/6Smoc-Tmem173tm2(hTMEM173)Smoc

Gene Summary

Gene Name
  • Synonyms :

    ERIS, MPYS, Mita, STING, STING-beta, 2610307O08Rik

  • NCBI ID :

    72512

  • MGI ID :

    1919762

  • Ensembl ID :

    ENSMUSG00000024349

  • Strain State :

    Embryo cryopreservation

Model Description

The endogenous mouse Tmem173 gene was replaced by human TMEM173 gene.

Validation Data

sting-cd4.png

Fig1 The expression of human STING in CD4+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD4+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

sting-cd8.png

Fig2 The expression of human STING in CD8+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD8+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

sting-3.png

Fig3 The expression of human STING in the heart and lung cells was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in the heart and lung cells . 

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