Strain Model Specification

hTREM2

Strain Name C57BL/6Smoc-Trem2tm4(hTRem2)/Smoc
Catalog Number NM-HU-2000083
Genetic Background C57BL/6Smoc
Gene Symbol Trem2
Synonyms TREM-2, Trem2a, Trem2b, Trem2c
NCBI ID 83433, , , ↗
MGI ID 1913150, , , ↗
Ensembl ID ENSMUSG00000023992, , , ↗
Strain State Embryo cryopreservation
Research Application Alzheimer's disease research;drug screening

Validation Data

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Fig1. Detection of TREM2 expression in brain by RT-PCR. Wild type: only one band at 344 bp with primers F1/R1(mTrem2);Homoygous: only one band at 308 bp with primers F2/R2(hTREM2); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. hTREM2 Expression in Tumor-infiltrating Macrophages in hTREM2 Mice Bearing MC38 Syngenic Tumors. (Anti-hTREM2 antibody provided by the third party)

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Fig3. hTREM2 Expression in Tumor-infiltrating Macrophages in hTREM2 Mice Bearing MC38 Syngenic Tumors. (The commercial Anti-hTREM2 antibody has cross reactivity with mouse TREM2)