Acan-IRES-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200143

Strain Name : C57BL/6Smoc-Acanem1(IRES-CreERT2)Smoc

Gene Summary

Gene Name

Model Description

A IRES-CreERT2 expression cassette was knocked into the Acan gene stop codon site via CRISPR/Cas9 mediated recombination.

Validation Data

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Fig. 1 CreERT2-mediated recombination in the joints of AcanCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the growth plate and articular cartilage of AcanCreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

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Fig. 2 Detection of tdTomato(red) in various tissues of AcanCreERT2/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the growth plate and articular cartilage after tamoxifen treatment. Tdtomato expression can be also detected in individual cells derived from the brown fat, spleen, testis, skin, skeletal muscle and cardiac valves. Tdtomato expression can not be detected in the brain, thymus, retina, lung, liver, stomach, submandibular gland, kidney, pancreas, intestine, colon, skin and myocardium. (For more detailed information please contact our technical advisor.)


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