Strain Model Specification

Acan-IRES-CreERT2

Strain Name C57BL/6Smoc-Acanem1(IRES-CreERT2)Smoc
Catalog Number NM-KI-200143
Genetic Background C57BL/6Smoc
Gene Symbol Acan
Synonyms Agc, cmd, Agc1, CSPCP, Cspg1, b2b183Clo
NCBI ID 11595 ↗
MGI ID 99602 ↗
Ensembl ID ENSMUSG00000030607 ↗
Strain State Sperm cryopreservation
Research Application Cre recombinase tool; When crossed with mice carrying a targeted floxed alleles, this strain is useful in eliminating tissue-specific conditional expression of the gene. These mice could be used to study degenerative cartilage diseases such as osteoarthritis and degenerative disc disease.

Validation Data

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Fig. 1 CreERT2-mediated recombination in the joints of AcanCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the growth plate and articular cartilage of AcanCreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

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Fig. 2 Detection of tdTomato(red) in various tissues of AcanCreERT2/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the growth plate and articular cartilage after tamoxifen treatment. Tdtomato expression can be also detected in individual cells derived from the brown fat, spleen, testis, skin, skeletal muscle and cardiac valves. Tdtomato expression can not be detected in the brain, thymus, retina, lung, liver, stomach, submandibular gland, kidney, pancreas, intestine, colon, skin and myocardium. (For more detailed information please contact our technical advisor.)