Strain Model Specification

hDMPK

Strain Name C57BL/6Smoc-Dmpktm1(hDMPK)Smoc
Catalog Number NM-HU-225084
Genetic Background C57BL/6Smoc
Gene Symbol Dmpk
Synonyms DM, DMK, Dm15, MDPK, MT-PK
NCBI ID 13400 ↗
MGI ID 94906 ↗
Ensembl ID ENSMUSG00000030409 ↗
Strain State Embryo cryopreservation

Validation Data

image.png

Fig.1 Detection of DMPK expression in heart by RT-PCR. 

Wild type: only one band at 259 bp with primers F1/R1(mDmpk);

Homozygous: only one band at 324 bp with primers F2/R2(hDMPK).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human DMPK expression in hDMPK knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous; PC, hela cells.

Note. The anti-human DMPK antibody cross-reacted with mouse DMPK and humanized DMPK. Arrow indicates expected molecular weight and asterisk indicates a nonspecific band.