R26-CAG-LSL-Kras*G12C-IRES-Luc

Nomenclature

C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-FRT-LSL-Kras(G12C)-IRES-Luciferase-polyA)Smoc

Cat. NO.

NM-KI-200323

Strain State

Repository Live

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Gene Summary

Gene Symbol
Gt(ROSA)26Sor

Model Description

A CAG-FRT-loxp-stop-loxp-Kras(G12C)-IRES-Luciferase-polyA expression cassette was knocked into the R26 locus.

Validation Data

图片1.png

Fig1. The lung histological images were observed under microscope after H&E staining (Black arrows indicated representativetumor).

Lung: Focal inflammatory cell infiltration, Florid proliferation of tubular and glandular structures,infiltrating growth of lung Adenocarcinoma. Left: left lobe; RU: right upper  lobe; RM: right middle lobe; RL: right lower Lobe; AL: accessory leaf.

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Fig2. The expression of luciferase in R26-CAG-LSL-Kras*G12C-IRES-Luc mice was detected by in vivo imaging. The expression of luciferase in mice was observed on days 0, 26 and 31 by nasal drops infected with AAV-Cre virus.


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