U-GEMMs

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-3xFlag-TARDBP(A315T)-IRES-GFP-WPRE-PA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-200019
Research Application:Amyotrophic lateral sclerosis(ALS) and frontotemporal lobar degeneration research
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-V5-TERT-IRES-Luciferase-2A-EGFP-WPRE-pA)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-18035
Research Application:Telomerase
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-200017
Research Application:Non-alcoholic fatty liver disease
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem(SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190098
Research Application:Colorectal carcinoma related.
Mice
Strain Name:BALB/cAnSmoc-Gt(ROSA)26Sorem1(CAG-loxP-STOP-lox2272-hTSHRa-loxP-lox2272-WPRE-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-234654
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-WNT1-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-190128
Research Application:Wnt1 signaling pathway, cancer research, etc
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-210138
Research Application:Fluorescent reporter Mice
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-hCD46-IRES-tdTomato-polyA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190087
Research Application:Immune-related
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-EZH2-IRES-luciferase-2A-tdTomato)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-18053
Research Application:Tumor research; drug screening
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Kozak-hIGF1R-IRES-EGFP-WPRE-pA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-231795
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