R26-CAG-LSL-Kras*G12C-IRES-Luc

Nomenclature

C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-FRT-LSL-Kras(G12C)-IRES-Luciferase-polyA)Smoc

Cat. NO.

NM-KI-200323

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Gt(ROSA)26Sor

Model Description

A CAG-FRT-loxp-stop-loxp-Kras(G12C)-IRES-Luciferase-polyA expression cassette was knocked into the R26 locus.

Validation Data

图片1.png

Fig1. The lung histological images were observed under microscope after H&E staining (Black arrows indicated representativetumor).

Lung: Focal inflammatory cell infiltration, Florid proliferation of tubular and glandular structures,infiltrating growth of lung Adenocarcinoma. Left: left lobe; RU: right upper  lobe; RM: right middle lobe; RL: right lower Lobe; AL: accessory leaf.

image.png

Fig2. The expression of luciferase in R26-CAG-LSL-Kras*G12C-IRES-Luc mice was detected by in vivo imaging. The expression of luciferase in mice was observed on days 0, 26 and 31 by nasal drops infected with AAV-Cre virus.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more