Standard GEMMs
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Strain Name：C57BL/6Smoc-Cdkn2Bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190621
Research Application：This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.
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Strain Name：C57BL/6Smoc-Cdkn2cem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-205110
Disease Connection：medulloblastoma
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Strain Name：C57BL/6Smoc-Cdkn2Cem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2114003
Disease Connection：medulloblastoma
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Strain Name：C57BL/6Smoc-Cdkn2Dem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2107647
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Strain Name：C57BL/6Smoc-Cdkn3em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-190622
Research Application：The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Strain Name：C57BL/6Smoc-Cdnfem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-205546
Research Application：secreted protein
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Strain Name：C57BL/6Smoc-Cdo1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2102213
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