Ace2-2A-CreERT2

Nomenclature

C57BL/6Smoc-Ace2em2(2A-CreERT2-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200187

Strain State

Repository Live

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Gene Summary

Gene Symbol
ACE2

Synonyms

ACEH

NCBI ID

59272

MGI ID

Null

Ensembl ID

ENSG00000130234

Pubmed

ACE2

Human Ortholog

ACE2

Model Description

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ace2 gene stop codon site. Ace2 encodes angiotensin I converting enzyme 2. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful for studying lung injury and kidney disease caused by SARS coronavirus infection.
Research Application：Cre recombinase tool

Validation Data

image.png

Fig. 1 CreERT2-mediated recombination in the lung of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pulmonary bronchial epithelial cells of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

image.png

Fig. 2 CreERT2-mediated recombination in the kidney of Ace2CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the proximal tubule of Ace2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 


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