Strain Model Specification

Enpp1-KO

Strain Name C57BL/6Smoc-Enpp1em2Smoc
Catalog Number NM-KO-200618
Genetic Background C57BL/6Smoc
Gene Symbol Enpp1
Synonyms 4833416E15Rik, CD203c, E-NPP1, Ly-41, NPP1, Npps, PC-1, Pca, Pca-1, Pdnp1, twy
NCBI ID 18605 ↗
MGI ID 97370 ↗
Ensembl ID ENSMUSG00000037370 ↗
Strain State Sperm cryopreservation
Research Application NAD metabolism and Riboflavin metabolism research; Cole Disease and Hypophosphatemic Rickets research. Model of spinal ligament ossification.

Validation Data


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Fig.1 Radiographic evidence of increased bone mineral density, calcification and bone fusion in Enpp1−/− mice (30 weeks, male).

Radiographs of Enpp1-/- mice show incresed bone mineral density and calcification at the joints of the hindlimb compared with wild type(*). Enpp1-/- mice also exhibit bone fusion at the joints of the hindlimb compared with wild type(#). No abnormality can be detected in Enpp1+/- mice.

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Fig. 2 CT analysis of the dermal sheath of vibrissae in Enpp1-/- mice.

The CT images of a representative Enpp1-/- cranium showed calcification of the dermal sheath of vibrissae.

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Fig. 3 Alizarin red staining of kidney and heart. Calcium deposits are stained red in the kidneys and hearts of Enpp1-/- mice, but not in Enpp1+/+ mice.

      image.png : Calcium deposits ;  image.png   : Blood cell