Strain Model Specification

Foxp3-IRES-DTRGFP

Strain Name C57BL/6Smoc-Foxp3em3(IRES-DTREGFP)Smoc
Catalog Number NM-KI-190046
Genetic Background C57BL/6Smoc
Gene Symbol Foxp3
Synonyms JM2, scurfin
NCBI ID 20371 ↗
MGI ID 1891436 ↗
Ensembl ID ENSMUSG00000039521 ↗
Strain State Repository Live

Validation Data

image.png

Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-IRES-DTRGFP KI mice. 

image.png

Fig2. Percentages of Tregs in the peripheral blood and spleen of Foxp3-IRES-DTRGFP KI mice treated with diphtheria toxin (DT).

foxp3-DTR-2.png

Fig3. The percent of  Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

foxp3-DTR-3.png

Fig4. The percent of  Treg+ and other immune cells in spleen and tumor of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

foxp3-DTR-4.png

Fig5.  The growth of MC38 tumors in Foxp3-IRES-DTRGFP mice and C57BL/6 mice. (In collaboration with CrownBio)