Strain Model Specification

hCD38(2)

Strain Name C57BL/6Smoc-Cd38tm2(CD38)Smoc
Catalog Number NM-HU-190059
Genetic Background C57BL/6Smoc
Gene Symbol Cd38
Synonyms I-19, ADPRC 1, Cd38-rs1
NCBI ID 12494, , ↗
MGI ID 107474, , ↗
Ensembl ID ENSMUSG00000029084, , ↗
Strain State Repository Live
Research Application Immunotherapy,cancer research,drug screening

Validation Data

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Fig1. hCD38 is highly expressed on both B cells and T cells in human PBMC.

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Fig2. m/hCD38 is highly expressed on blood and spleen-derived B cells in hCD38 knockin mice.

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Fig3. m/hCD38 can be detected on blood-derived T cells in hCD38 knockin mice.

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Fig4. m/hCD38 can be detected on spleen-derived T cells in hCD38 knockin mice.

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Fig5. In vivo anti-tumor effect of Daratumumab in hCD38 knockin mice. Homozygous humanized CD38 mice were inoculated with E.G7-OVA T lymphoma cells. The results showed: Daratumumab , a drug targeting human CD38, showed a very significant anti-tumor effect , demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.（ In cooperation with Crownbio）

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Fig6. Binding assay of Daratumumab to hCD38-derived B cells.（ In cooperation with Crownbio）

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Fig7. Binding assay of Daratumumab to hCD38-derived T cells.（ In cooperation with Crownbio）