Strain Model Specification

hCD4

Strain Name C57BL/6Smoc-Cd4tm1(hCD4) Smoc
Catalog Number NM-HU-00115
Genetic Background C57BL/6Smoc
Gene Symbol Cd4
Synonyms L3T4, Ly-4
NCBI ID 12504 ↗
MGI ID 88335 ↗
Ensembl ID ENSMUSG00000023274 ↗
Strain State Embryo cryopreservation
Research Application Immunotherapy,cancer research,drug screening

Validation Data

CD4-hu-1.png

CD4-hu-2.png

Fig 1. Flow cytometric analysis of the T cell subtype proportions in peripheral blood from control and the humanized CD4 mouse model. 

 A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05，**P<0.01.

CD4-hu-3.png

CD4-hu-4.png

Fig2. Flow cytometric analysis of the T cell subtype proportions in thymus from control and the humanized CD4 mouse model. A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05.

image.png

Fig3. Expression characterization of hCD4 in hCD4 KI mice.