Strain Model Specification

hPD-1(BALB/c)

Strain Name BALB/cAnSmoc-Pdcd1em1(hPDCD1)Smoc
Catalog Number NM-HU-190079
Genetic Background BALB/cAnSmoc
Gene Symbol PD1
Synonyms PD-1, Pdc1, Ly101
NCBI ID 18566 ↗
MGI ID 104879 ↗
Ensembl ID ENSMUSG00000026285 ↗
Strain State Embryo cryopreservation

Validation Data

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Fig1. Expression of PD-1 in the activated spleen lymphocytes of homozygous humanized PD-1 BALB/c KI mice is detected by FACS.

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Fig2. Detection of hPD-1 expression on B cells, T cells and NKs in Bone Marrow in hPD-1 KI mice.

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Fig3. In vivo validation of homozygous BALB/c-hPD1 mice. The homozygous BALB/c-hPD1 mice were inoculated with CT26 cells, and randomly assigned to different groups (n=7) when the tumor grew to a volume of 100 mm3. A combinatorial treatment of anti-hPD1 antibody Keytruda  and entinostat (ENT; a class I HDAC inhibitor) demonstrated a noticeable efficacy improvement compared to the same dose of single agent (A) without affecting the animal body weight (B).

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Fig7. In vivo validation of homozygous BALB/c-hPD1 mice. The homozygous BALB/c-hPD1 mice were inoculated with CT26 cells, and randomly assigned to different groups (n=6) when the tumor grew to a volume of 65 mm3. A combinatorial treatment of anti-hPD1 antibody Opdivo  and anti-mCTLA antibody demonstrated a noticeable efficacy improvement compared to the same dose of single agent (A) without affecting the animal body weight (B). (In collaboration with Crownbio)