Lyz2-2A-CreERT2
Nomenclature
C57BL/6Smoc-Lyz2em1(2A-CreERT2-WPRE-pA)Smoc
Cat. NO.
NM-KI-18018
Strain State
Repository Live
Gene Summary
Gene Symbol
Lyz2
Model Description
A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Lyz2 gene via homologous recombination to establish a tamoxifen inducible Lyz2-CreERT2 tool stain. This strain can be used to knockout target gene in Lyz2+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.
Research Application：Cre recombinase tool
*Literature published using this strain should indicate: Lyz2-2A-CreERT2 mice (Cat. NO. NM-KI-18018) were purchased from Shanghai Model Organisms Center, Inc..
Validation Data
Fig1 Evaluation of CreERT2 recombination in Lyz2 Cre+/-;R26 tdT+/- mice.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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Milestones
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