Krt14-CreERT2

Nomenclature

C57BL/6Smoc-Krt14em2(CreERT2-Wpre-polyA)Smoc

Cat. NO.

NM-KI-190024

Strain State

Repository Live

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Gene Summary

Gene Symbol
Krt14

Synonyms

K14; CK-14; Krt1-14; AI626930; Krt-1.14

NCBI ID

16664

MGI ID

96688

Ensembl ID

ENSMUSG00000045545

Pubmed

Krt14

Human Ortholog

KRT14

Model Description

A CreERT2-Wpre-polyA expression cassette was knocked into initiation codon ATG site of the Krt14 gene.
Research Application：Cre recombinase tool

Validation Data

微信截图_20190716101355.png

Fig1 CreERT2-mediated recombination in Skin, Tongue & Esophagus of Krt14 CreERT2+/-;R26 tdTomato+/- mice.

A， Krt14-CreERT2+/- ; Rosa26 tdTomato+/- ; Tamoxifen

B， Krt14-CreERT2+/-; Rosa26 tdTomato+/- 

C， Rosa26 tdTomato+/-


微信截图_20190716101755.png

Fig2 Confocal images showing expression of tdTomato in Skin, Tongue & Esophagus of Krt14 CreERT2+/-;R26 tdTomato +/- mice.

A， Krt14-CreERT2+/- ; Rosa26 tdTomato+/- ; Tamoxifen

B， Krt14-CreERT2+/-; Rosa26 tdTomato+/- 

C， Rosa26 tdTomato+/-

Publications

A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL
References：Cell Research

Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma
References：Theranostics

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