Muc2-2A-CreERT2-IRES-tdTomato

Nomenclature

C57BL/6Smoc-Muc2em1(2A-CreERT2-tdTomato-Wpre-pA)Smoc

Cat. NO.

NM-KI-200301

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol

Synonyms

MCM，wnn，2010015E03Rik

NCBI ID

17831

MGI ID

1339364

Ensembl ID

ENSMUSG00000025515

Pubmed

Human Ortholog

MUC2

Model Description

2A-CreERT2-tdTomato-Wpre-pA expression cassette was knocked into the Muc2 gene stop codon site.

Validation Data

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Fig 1. Active tdTomato expression was observed in the large intestine of Muc2CreERT2-IRES-tdTomato/+  mouse. WT, wild type as control.

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Fig 2. Active tdTomato expression was observed  in the small intestine of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

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Fig 3. No obvious tdTomato signal was observed in the stomach of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

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Fig 4. Active tdTomato signal was observed in the colon of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

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Fig 5. Active tdTomato signal was observed in the cecum of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

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Fig 6. TdTomato signal was observed in the small intestine of Muc2CreERT2-IRES-tdTomato/+ mouse.WT, wild type as control.


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Fig 7. No obvious tdTomato signal was observed in the stomach of Muc2CreERT2-IRES-tdTomato/+ mouse. WT, wild type as control.

Reference(s)

Slowed Intestinal Transit Induced by Less Mucus in Intestinal Goblet Cell Piezo1-Deficient Mice through Impaired Epithelial Homeostasis
References：MDPI

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