Ins1-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200107

Strain Name : C57BL/6Smoc-Ins1em1(CreERT2-pA)Smoc

Gene Summary

Gene Name

Model Description

A CreERT2-pA expression cassette was knocked into the Ins1 gene start codon site. Ins1(insulin I) gene encodes insulin. This strain is useful in studying diabetes. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cre-expressing cells after tamoxifen treatment.

Validation Data

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Fig. 1 CreERT2-mediated recombination in the pancreas of Ins1CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pancreatic islet cells of Ins1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

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Fig. 2 Detection of tdTomato(red) in various tissues of Ins1CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. Tdtomato was expressed in the pancreas islet and individual cells of thymus. TdTomato can not be detected in the brain, retina, heart, lung, stomach, salivary gland, kidney, colon, intestine, spleen, ovary, muscle and skin. (For more detailed information please contact our technical advisor.)


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