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Home / Immune-Related Mice / Immunodeficient / B2m-KO

B2m-KO

Background : C57BL/6Smoc

Catalog : NM-KO-18021

Strain Name : C57BL/6Smoc-B2mem3Smoc

Gene Summary

Gene Name

Model Description

Exon2-3 of B2m gene were deleted to generate Ifngr1 knockout mice.

Validation Data

b2m流式.png

Fig1 . There are few CD8+ cytotoxic T-cells and increase in CD4+ T-cells in B2M knockout mice. Immune responses involving CD8+T-cells are severely deficient providing a model to assess the role of CD8+ cells and class I MHC in various experimental systems. 

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