hHER2

Background : C57BL/6Smoc

Catalog : NM-HU-200115

Strain Name : C57BL/6Smoc-Erbb2tm1(hERBB2)Smoc

Gene Summary

Gene Name
  • Synonyms :

    Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, l11Jus8, mKIAA3023

  • NCBI ID :

    13866

  • MGI ID :

    95410

  • Ensembl ID :

    ENSMUSG00000062312

  • Strain State :

    活体

Model Description

The endogenous mouse Erbb2 gene was replaced by human ERBB2 gene.

Validation Data

image.png

Fig1. Detection of HER2 expression by RT-PCR. 

Wild type: only one band at 375 bp with primers F1/R1 (mHer2);

Homozygous: one band at 223 bp with primers F2/R2 (hHER2).

Abbr. M, DNA marker; HO, homozygous;  WT, wild type.

image.png

Fig2. Detection of HER2 expression in homozygous hHER2 mice by Western Blot. 

(Note: The HER2 antibody cross-reacted with mHER2 and humanized HER2)

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