hIL2/hIL2RA - Genobiotx

Gene Summary

Gene Name

Synonyms :
Il-2, I, CD25, Il2r, Ly-4, Ly-43
NCBI ID :
16183 16184
MGI ID :
96548 96549
Ensembl ID :
ENSMUSG00000027720 ENSMUSG00000026770
Strain State :
胚胎冻存

Model Description

hIL2(NM-HU-190048) was crossed with hIL2R(NM-HU-190064) to generate IhIL2/hIL2RA mice.

Validation Data

Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).

Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (In collaboration with CrownBio).

Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (In collaboration with CrownBio).

Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse (In collaboration with CrownBio).

Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (In collaboration with CrownBio).

Related Strains

Product

Product Catalog

Background

hIL3(NMG)

NM-NSG-007

NOD

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huHSC-(NMG)

NM-NSG-017

huHSC

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R26-CAG-LSL-hFCGR2A-IRES-EGFP

NM-KI-200229

C57BL/6Smoc

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R26-CAG-LSL-hFCGR3A-IRES-tdTomato

NM-KI-200255

C57BL/6Smoc

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R26-CAG-LSL-hSOS-F-tdTomato

NM-KI-200020

C57BL/6Smoc

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R26-CAG-LSL-hMLL-AF9-IRES-Luc-2A-tdTomato

NM-KI-190114

C57BL/6Smoc

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hTNFRSF10C

NM-HU-230344

C57BL/6Smoc

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hANGPTL3(3)

NM-HU-210037

C57BL/6Smoc

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hTIM4

NM-HU-225042

C57BL/6Smoc

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hFCGR1A

NM-HU-2000072

C57BL/6Smoc

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More..