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Customized Genetically Engineered Mouse Models

Combined with versatile technical platforms, GenoBioTX guarantees every custom model created is intended to fulfill diversified requirements from researchers. We offer not only classic knockout and knockin models, but also conditional point mutations and conditional knockouts with reporters. Our custom models will be the cornerstone of your research

Comparison of Three Gene Modification Technologies

Technology
Key points
Duration
Applications
Pros and Cons
CRISPR/ Cas9
Cas9 nuclease cuts specific sites.
3-9 months
Gene knockout, conditional knockout, gene knock-in, point mutation, humanization.
Pros-Short project cycle, high efficiency. Lower risk of off-target effects through sequencing verification. Successive generations can remove off-target sites. Cons-Potential risk of off-target effects, but manageable by choosing appropriate sgRNA. 
ESC Targeting
Homologous recombination modifies genes.
9-12 months
Gene knockout, conditional knockout, gene knock-in, point mutation, humanization.
Pros-Mature technology, stable results, no off-target effects. Can achieve large segment recombinationCons-Longer project duration.
PiggyBac Transposon Technology
Transposon integrates DNA segments into the genome. 
3-6 months
Gene overexpression
Pros-Simple plamid insertion, high expression rate. Multiple insertion sites. Cons-Subsequent experiments require establishing stable lines. 

Model Classifications

Gain of Function Loss of Function

Work Flow

What We Provide/Our Advantages

In-depth feasibility evaluation before your project starts

  • More rational model design to avoid artifactual phenotypes
  • More detailed project feasibility assessment
  • More accurate timelines

An efficient production line with rigorous quality control

  • Shortened project trunaround time
  • Guaranteed germline transmission of genetic modification in models generated from the ES cell targeting and CRISPR gene editing technologies

Regular and rigorous reporting during project implementation

  • A dedicated project manager
  • Seamless flow of information
  • One-on-one, face-to-face communication

A professional breeding support team and advanced animal breeding facilities

  • Animal health reports
  • Global delivery
  • Flexible delivery options
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