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Combined with versatile technical platforms, GenoBioTX guarantees every custom model created is intended to fulfill diversified requirements from researchers. We offer not only classic knockout and knockin models, but also conditional point mutations and conditional knockouts with reporters. Our custom models will be the cornerstone of your research.
We provide one-stop animal model services aimed at accelerating translational studies of life science and medicine.
| Technology | Key Points | Duration | Applications | Pros and Cons |
|---|---|---|---|---|
| CRISPR / Cas9 | Cas9 nuclease cuts specific sites. | 3-9 months |
Gene knockout, conditional knockout, gene knock-in, point mutation, humanization. |
Pros – Short project cycle, high efficiency. Lower risk of
off-target effects through sequencing verification. Successive generations
can remove off-target sites. Cons – Potential risk of off-target effects, but manageable by choosing appropriate sgRNA. |
| ESC Targeting | Homologous recombination modifies genes. | 9-12 months |
Gene knockout, conditional knockout, gene knock-in, point mutation, humanization. |
Pros – Mature technology, stable results, no off-target
effects. Can achieve large segment recombination. Cons – Longer project duration. |
| PiggyBac Transposon Technology |
Transposon integrates DNA segments into the genome. |
3-6 months | Gene overexpression. |
Pros – Simple plamid insertion, high expression rate.
Multiple insertion sites. Cons – Subsequent experiments require establishing stable lines. |
Gain of Function
Loss of Function
Professional technical consultants will communicate with you in detail to determine the customization needs, including the type of model, specific genes, and the delivery conditions.
A professional technical team will analyze your customization needs and communicate with you to confirm the feasibility of the plan.
After confirming the plan, sign the model customization contract.
We will execute the project according to the confirmed analysis plan and contract content.
Technical consultants will report the project progress to you as needed.
When the project meets the predetermined requirements, we will notify you in advance to prepare for delivery.
Upon model delivery, provide a written project summary report, offer subsequent feeding and breeding recommendations, and process payment.
Please fill in the order form and we will contact you within 2 working days.
