hGITR

Background : C57BL/6Smoc

Catalog : NM-HU-00096

Strain Name :

C57BL/6Smoc-Tnfrsf18tm1(hTNFRSF18) Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Tnfrsf18 gene was replaced by human TNFRSF18 gene .

Validation Data

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Figure 1. Expression of humanized GITR in the spleen lymphocytes of humanized GITR mice is detected by FACS.Staining of spleen lymphocytes collected from heterozygous humanized GITR mice, while the expression of humanized GITR is detected by FACS.The results showed that the active expression of humanized GITR can be detected in the spleen lymphocytes collected from heterozygous humanized GITR mice.

hGITR 流式图.jpg


Figure 2. Detection of GITR expression in peripheral blood cells of humanized GITR mice. The FACS results of peripheral blood cells showed that the active expression of humanized GITR was detected in T cells collected from heterozygous humanized GITR mice.(Completed in collaboration with CrownBio).

NM-HU-00096-hTNFRSF18-补充.png

Fig3. Analysis of human GITR expression in the spleen by FACS. The homozygous KI mouse expresses human GITR on the CD4+ T cells.

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