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U-GEMMs

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Mice

Axl-KO

Strain Name：C57BL/6Smoc-Axlem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200044

Exon 3 of Axl gene was deleted to generate Axl knockout mice.

Mice

hCCR5

Strain Name：C57BL/6Smoc-Ccr5tm1(hCCR5)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000065

The endogenous mouse Ccr5 gene was replaced by human CCR5 gene.

Mice

Trp53-Flox

Strain Name：C57BL/6Smoc-Trp53tm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18005

These Trp53 flox mice possess loxP sites flanking exons 5-7 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Ccr2-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Ccr2em1(IRES-DTRGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210102

IRES-DTRGFP expression cassette was knocked into the Ccr2 gene .

Mice

hSPP1

Strain Name：C57BL/6Smoc-Spp1tm1(hSPP1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225037

The endogenous mouse Spp1 gene was replaced by human SPP1 gene.

Mice

hIL12A

Strain Name：C57BL/6Smoc-Il12atm3(hIL12A)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000056

The endogenous mouse Il12a gene was replaced by human IL12A gene.

Mice

R26-CAG-LSL-dCas9-VPR-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-dCas9-VPR-IRES-EGFP-WPRE-pA)
Strain State：Repository Live | Cat. NO.：NM-KI-18004

These mice harbor a CAG-LSL-dCas9-VPR(VP64-p65-Rta)-eGFP-pA conditional expression cassette in mouse Rosa26 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

Mice

hCCR8(2)/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8em3(hCCR8)Ctla4em1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220074

hCTLA4 (NM-HU-00014) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hCCR8(2)/hCTLA4 mice．

Mice

Tagln-Cre

Strain Name：C57BL/6Smoc-Taglnem1(Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200144

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.

Mice

H11-CAG-RSR-EYFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-RSR-EYFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18056

A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.

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