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U-GEMMs

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Mice

Il16-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il16em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00028

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il16.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hTNFR2

Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190010

The endogenous mouse Tnfrsf1b gene was replaced by human TNFRSF1B gene.

Mice

CMV-GFP-Tg

Strain Name：B6.Cg-Tg(CMV-GFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-TG-00006

These mice carry enhanced green fluorescent protein gene driven by CMV promoter.

Mice

Abcb4-KO(FVB)

Strain Name：FVB-Abcb4em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200584

Exon 3-4 of Abcb4 gene was deleted to generate Abcb4 knockout mice.

Mice

Cd19-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Cd19em2(IRES-DTREGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190042

A IRES-DTREGFP expression cassette was knocked into the Cd19 gene stop codon site.

Mice

hTNFa-Tg

Strain Name：C57BL/6Smoc-Tgtn(hTNFa promoter-hTNFa-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-200004

These transgenic mice harbor hTNFa promoter-hTNFa-pA expression cassette.

Mice

hIL17A/hIL17F

Strain Name：C57BL/6Smoc-Il17atm1(hIL17A)Il17fem2(hIL17F)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200281

The endogenous mouse Il17a&Il17f genes were replaced by human IL17A&IL17F gene.

Mice

Lgr5-EGFP-IRES-CreERT2

Strain Name：C57BL/6Smoc-Lgr5em1(EGFP-IRES-creERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200154

A EGFP-IRES-creERT2-WPRE-polyA expression cassette was knocked into the Lgr5 gene start codon site.

Mice

CAG-Dre-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-Dre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-TG-00026

These transgenic mice carry Dre recombinase driven by CAG promoter.

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