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U-GEMMs

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Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

Mice

hPD-1/hLAG3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Lag3em1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00101

hPD-1(NM-HU-00015) was crossed with hLAG3(NM-HU-00049)to generate hPD-1/hLAG3 mice

Mice

hCD24

Strain Name：C57BL/6Smoc-Cd24atm1(hCD24)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000060

The endogenous mouse Cd24a gene was replaced by human CD24 gene. While hCD24(2)(Stock No.NM-HU-215025) mice function similarly to hCD24 mice, for more detailed information please contact our technical advisor.

Mice

hCSF1

Strain Name：C57BL/6Smoc-Csf1tm2(CSF1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190043

The endogenous mouse Csf1 gene was replaced by human CSF1 gene.

Mice

hPD-1/hCTLA-4

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Ctla4em1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00079

hPD-1(NM-HU-00015) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

Braf-Flox

Strain Name：C57BL/6Smoc-Brafem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200073

These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene.

Mice

hGIPR

Strain Name：C57BL/6Smoc-Giprtm1(hGIPR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225064

The endogenous mouse Gipr gene was replaced by human GIPR gene.

Mice

Wnt1-Dre

Strain Name：C57BL/6Smoc-Wnt1em1(Dre-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200176

A Dre-Wpre-polyA expression cassette was knocked into the Wnt1 gene start codon site. Wnt1 gene is involved in stem cell poliferation in multiple systems, including the hematopoietic system and the embryonic nervous system. This strain may be useful for studying central nervous system development. When crossed with a strain carrying a gene flanked by rox sites, the flanked gene will be removed in cells expressing dre.

Mice

Cdh5-rtTA-TetO-Cre

Strain Name：B6;129S-Cdh5tm1(rtTA-tetO-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18006

These mice harbor an M2rtTA-Wpre-polyA-attp-PGK-Neo-polyA-attb-long insulator-tetO-Cre-FRT-Wpre-FRT-polyA-long insulator cassette before ATG of the Cdh5 locus generated homologous recombination.

Mice

Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Cd8aem1(V5-IRES-luci-2A-EGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18030

A V5-IRES-luci-2A-EGFP expression cassette was inserted before the stop codon TAA of mouse Cd8a gene to establish a multi-labeled knockin model with V5, luciferase and EGFP fluorescent protein.

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