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U-GEMMs

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Mice

Ifng-Venus-Luc

Strain Name：C57BL/6Smoc-Ifngem1(IRES-Venus-Luci)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18041

An IRES-Venus-Luci co-expression cassette was inserted in 3'UTR region of Ifng gene.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

hTNFRSF10B

Strain Name：C57BL/6Smoc-Tnfrsf10bem1(hTNFRSF10B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210005

The endogenous mice Tnfrsf10B gene was replaced by human TNFRSF10B gene

Mice

hPVRIG

Strain Name：C57BL/6Smoc-Pvrigem1(hPVRIG)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210008

The endogenous mice Pvrig gene was replaced by human PVRIG gene While hPVRIG(2)(Stock No.NM-HU-215013) mice function similarly to hPVRIG mice, for more detailed information please contact our technical advisor.

Mice

hCLDN6

Strain Name：C57BL/6Smoc-Cldn6em1(hCLDN6)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225034

The endogenous mouse Cldn6 gene was replaced by human CLDN6 gene.

Mice

Bhlha15-CreERT2

Strain Name：C57BL/6Smoc-Bhlha15em1(CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200080

The coding region of Bhlha15 gene was replaced by a CreERT2 expression cassette.Besides,a kozak-CreERT2-WPRE-polyA expression cassette were knock into the Bhlha15 gene start codon site to generate Bhlha15-CreERT2(2)(Stock No. NM-KI-200158) mice. Bhlha15(basic helix-loop-helix family member a15) is also known as Mist1. The gene product is involved in controlling exocrine secretion from the pancreas, small intestine and stomach. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Bhlha15.

Mice

Il1f10-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1f10em1(Luc-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00060

A Luciferase-2a-egfp-polyA cassette was inserted at ATG site of mouse Il1f10 gene.

Mice

Foxp3-IRES-tdTomato-2A-CreERT2

Strain Name：C57BL/6Smoc-Foxp3em4(IRES-tdTomato-2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190120

A IRES-tdTomato-2A-CreERT2 expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

R26-CAG-LSL-hEGFR*L858R/T790M-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190068

These mice harbor a CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCTLA-4/hTIGIT

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Tigitem1(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210399

hCTLA4(NM-HU-00014) was crossed with hTIGIT(NM-HU-00053) to generate hCTLA4/hTIGIT mice.

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