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U-GEMMs

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Mice

hPD-1/hTIGIT/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Tigitem1(hTIGIT) Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190029

hPD-1(NM-HU-00015),hTIGIT(NM-HU-00053) were crossed with hTIM3(NM-HU-00054) to generate hPD-1/hTIGIT/hTIM3.

Mice

Nos1-CreERT2

Strain Name：C57BL/6Smoc-Nos1em1(CreERT2-SV40polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200091

A CreERT2-SV40polyA expression cassette was knocked into the Nos1 gene start codon site.

Mice

Slc18a3-2A-eGFP

Strain Name：C57BL/6Smoc-Slc18a3em(2A-eGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220181

2A-eGFP expression cassette was knocked into the Slc18a3 gene stop codon site.

Mice

hIL2/hIL2RA/hIL2RB/hIL2RG

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)Il2rgem1(IL2RG)Il2rbtm1(hIL2RB)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210415

hIL2/hIL2RA(NM-HU-200275) was crossed with hIL2RA/hIL2RB/hIL2RG(NM-HU-210414) to generate hIL2/hIL2RA/hIL2RB/hIL2RG mice.

Mice

hCYP2D

Strain Name：C57BL/6Smoc-Cyp2dtm(hCYP2D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215016

The endogenous mouse Cyp2d gene was replaced by human CYP2D gene.

Mice

Il17f-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il17fem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00031

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il17f.

Mice

Avp-IRES-Cre

Strain Name：C57BL/6Smoc-Avpem1(IRES2-Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200142

A IRES2-Cre-WPRE-polyA expression cassette was knocked into the Avp gene stop codon site. Avp encodes arginine vasopressin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying hypertension.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Snca-KO

Strain Name：C57BL/6Smoc-Sncaem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190380

This Snca knockout mouse model was generated by knocking out the exon4 region of the Snca.

Mice

hIL2

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190048

The endogenous mouse Il2 gene was replaced by human IL2 gene.

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