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U-GEMMs

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Mice

hPD-L1(2)/hCD28

Strain Name：C57BL/6Smoc-Cd274em2(hPD-L1)Cd28em2(hCD28)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210370

hPD-L1(2)(NM-HU-190039) was crossed with hCD28(NM-HU-190011）to generate hPD-L1(2)/hCD28 mice

Mice

hIL4

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190071

The endogenous mouse Il4 gene was completely or partially replaced by human IL4 gene via ESC targeting.

Mice

R26-CAG-Cas9

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-Cas9)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00120

These mice were established by crossing R26-(CAG-LSL-Cas9) and EIIA mice together.

Mice

hIL11

Strain Name：C57BL/6Smoc-Il11em1(hIL11)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204981

The endogenous mice Il11 gene was replaced by human IL11 gene.

Mice

Foxp3-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Foxp3em1(IRES-Luci-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200065

A IRES-luci-2A-tdTomato expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

hFCGR2B/hOX40

Strain Name：C57BL/6Smoc-Fcgrt2Bem2(hFCGRT2B)Tnfrsf4em1(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200265

hFCGR2B（NM-HU-2000010） was crossed with hOX40（NM-HU-00041）to generate hFCGR2B/hCD40 mice

Mice

Sox9-IRES-CreERT2

Strain Name：C57BL/6Smoc-Sox9em(IRES-CreERT2-SV40pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-204996

IRES-CreERT2-SV40pA expression cassette was knocked into the Sox9 gene .

Mice

Il1f6-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il1f6em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00017

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1f6.

Mice

hPD-1/hPD-L1/hPD-L2

Strain Name：C57BL/6Smoc-Pdcd1lg2em1(hPDCD1LG2)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190060

The endogenous mouse Pd-1/Pd-l1/Pdcd1lg2 gene was replaced by human PD-1/PD-L1/PDCD1LG2 gene.

Mice

Shh-CreERT2

Strain Name：C57BL/6Smoc-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145

A CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site.

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