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U-GEMMs

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Mice

Foxn1-IRES-Cre

Strain Name:C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-200106

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

Il4-IRES-tdTomato

Strain Name:C57BL/6Smoc-Il4em3(IRES-tdTomato-polyA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200028

A IRES-tdTomato-polyA expression cassette was knocked into the Il4 gene stop codon site.

Mice

Ly6a-2A-Cre

Strain Name:C57BL/6Smoc-Ly6aem1(2A-iCre)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190028

A 2A-iCre expression cassette was knocked into the Ly6a gene stop codon site.

Mice

hIGHG4

Strain Name:C57BL/6Smoc-Ighg1tm1(hIGHG4)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-225092

The endogenous mouse Ighg1 gene was replaced by human IGHG4 gene.

Mice

hCD3EDG

Strain Name:C57BL/6-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)/CbSmoc
Strain State:Repository Live | Cat. NO.:NM-HU-220120

The endogenous mouse Cd3e/Cd3d/Cd3g genes were replaced by human CD3E/CD3D/CD3G gene.

Mice

hSIRPA(2)/hCD47/hPD-1/hPD-L1

Strain Name:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210358

hSIRPA(2)(NM-HU-18015),hCD47(NM-HU-00050), hPD-1(NM-HU-00015), hPD-L1(NM-HU-00062)was crossed together to generate hSIRPA(2)/hCD47/hPD-1/hPD-L1 mice.

Mice

Penk-IRES-Cre

Strain Name:C57BL/6Smoc-Penkem1(IRES2-iCre)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200088

A IRES2-iCre expression cassette was knocked into the Penk gene stop codon site.

Mice

Arntl-Flox

Strain Name:C57BL/6Smoc-Arntlem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-200063

These mice carry loxP sites flanking exon 8 of Arntl gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Arntl gene.

Mice

Cd207-2A-CreERT2

Strain Name:C57BL/6Smoc-Cd207em2(2A-CreERT2-WPRE-polyA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-200021

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Cd207 gene stop codon site.

Mice

hSIRPA(2)/hCD47/hPD-1/hPD-L1(2)

Strain Name:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)Pdcd1em1(hPDCD1)Cd274em2(hPD-L1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-220029

hSIRPA(2)(NM-HU-18015), hCD47(NM-HU-00050) and hPD-1(NM-HU-00015) was crossed with hPD-L1(2)(NM-HU-190039)to generate hSIRPA(2)/hCD47/hPD-1/hPD-L1(2) mice.

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