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U-GEMMs

About 42,416 results
Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocH2-Ab1em1SmocH2-Aaem1SmocH2-Eb1em1SmocH2-Eb2em1SmocH2-Ea-psem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

Pax7-IRES-CreERT2

Strain Name：C57BL/6Smoc-Pax7em1(IRES-Cre-ERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200099

A IRES-Cre-ERT2 expression cassette was knocked into the Pax7 gene stop codon site. Pax7 is expressed in myogenic progenitor cells. Pax7 is essential for the myogenic potential, survival, and proliferation of myogenic progenitors. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Pax7 after tamoxifen treatment.

Mice

Foxj1-EGFP-CreERT2

Strain Name：C57BL/6Smoc-Foxj1em1(GFP-CreERT2-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200133

A GFP-CreERT2-polyA expression cassette was knocked into the Foxj1 gene start codon site.

Mice

hGNRHR

Strain Name：C57BL/6Smoc-Gnrhrem(hGNRHR)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-220137

The endogenous mouse Gnrhr gene was replaced by human GNRHR gene.

Mice

Slc6a11-CreERT2

Strain Name：C57BL/6Smoc-Slc6a11em1(CreERT2-polyA(SV40)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200130

A CreERT2-polyA expression cassette was knocked into the Slc6a11 gene start codon site. Slc6a11 encodes GAT3 (Gabt4), a sodium-dependent transporter that uptakes the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which ends the GABA neurotransmission. When Slc6a11-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLC6A11positive cells. Defects in Slc6a11 may result in epilepsy or behavioral and intellectual defects.

Mice

hCD3EDG/h4-1BB(2)

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Tnfrsf9tm2(TNFRSF9) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220110

hCD3EDG(NM-HU-220120) mice were crossed with h4-1BB(2)(NM-HU-190077) to generate hCD3EDG/h4-1BB(2) mice.

Mice

Dmpk-KO

Strain Name：C57BL/6Smoc-Dmpkem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200635

Exon 1-7 of Dmpk gene was deleted to generate Dmpk knockout mice.

Mice

hNR1I3

Strain Name：C57BL/6Smoc-Nr1i3tm1(hNR1I3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200253

The endogenous mice Nr1i3 gene was replaced by human NR1I3 gene.

Mice

Agrp-Dre

Strain Name：C57BL/6Smoc-Agrpem(Kozak-Dre-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-220331

Kozak-Dre-WPRE-pA expression cassette was knocked into the Agrp gene start codon site.

Mice

R26-CAG-LSL-Kdm7a-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Kdm7a-2A-tdTomato-Wpre-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200297

A CAG-LSL-Kdm7a-2A-tdTomato-Wpre-pA expression cassette was knocked into the Rosa26 locus.

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