Figure 1. Expression of human CD47 on A20-hCD47 cells was confirmed by flow cytometry.
A20-hCD47 cells and wild type A20 cells were stained with species-specific anti-CD47 antibodies. FACS analysis shows that human CD47 but not mouse CD47 was exclusively detectable on A20-hCD47 cells.
Figure 2. In vivo tumor growth curves in humanized A20-hCD47 syngeneic model.
BALB/c mice were subcutaneously injected 5×105 A20-hCD47 cells compared with wild type A20 cells as control. Tumor growth was monitored by measuring tumor size from day 11 after subcutaneous implantation.
Data shows that there were no significant differences between A20-hCD47 cells and wild type A20 cells in either tumorigenicity or tumor growth.
Figure 3. FACS analysis of CD47 expression on tumor cells derived from humanized A20-hCD47 syngeneic model with species-specific anti-CD47 antibodies.
Data shows that human CD47 knock-in tumor exclusively express human CD47 but not mouse CD47.
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