Strain Model Specification

Arc-CreERT2

Strain Name C57BL/6Smoc-Arcem1(CreERT2-SV40-pA)Smoc
Catalog Number NM-KI-200101
Genetic Background C57BL/6Smoc
Gene Symbol Arc
Synonyms mArc, Arc3.1, C86064, arg3.1
NCBI ID 11838 ↗
MGI ID 88067 ↗
Ensembl ID ENSMUSG00000022602 ↗
Strain State Sperm cryopreservation
Research Application By mating the reporter mice with CreERT2-expressing mice, Arc positive cells derived from double-positive mice were permanently labeled by fluorescent protein after tamoxifen treatment. Arc, a immediate-early gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.

Validation Data

Arc-CreERT2-1.png

Fig.1  Detection of tdTomato (red) in the  brain of ArcCreERT2/+; Rosa26tdTomato/+  mouse after tamoxifen treatment. CreERT2-mediated recombination in the brain can be induced by tamoxifen. Some leakiness were detected in the hippocampus and thalamus prior to tamoxifen exposure.

Arc-CreERT2-2.png

Fig. 2 Detection of tdTomato (red) in various tissues of ArcCreERT2/+; Rosa26tdTomato/+ mice. CreERT2-mediated recombination in the brain, liver, kidney, pancreas, lung, stomach, submandibular gland, skin, testis and epididymis, pituitary gland and eye can be induced by tamoxifen. Some leakiness were detected in the brain and brown fat prior to tamoxifen exposure. (For more detailed information please contact our technical advisor.)