Atp4b-IRES-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-210118

Strain Name :

C57BL/6Smoc-Atp4bem1(IRES-CreERT2-WPRE-pA)Smoc

Gene Summary

Gene Name

Model Description

An IRES-CreERT2-WPRE-pA expression cassette was knocked into the Atp4b gene start codon site.Besides,An IRES-CreERT2 expression cassette were knock into the Bhlha15 gene stop codon site to generate Atp4b-IRES-CreERT2(2)(Stock No. NM-KI-210119) mice.

Validation Data

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Fig1. CreERT2-mediated recombination in the stomach of Atp4bCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the stomach of Atp4bCreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. Some leakiness was detected prior to tamoxifen exposure.

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Fig2. Detection of tdTomato (red) in various tissues of  Atp4bCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. Tdtomato was expressed in the glandular stomach. Tdtomato can also be detected in the pituitary, thymus, salivary glands, brown adipose tissue, spleen, pancreas, and muscle. Some leakiness was detected prior to tamoxifen exposure. TdTomato expression can not be detected in the brain, liver, lung, large intestine, small intestine, kidney or skin.

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