Strain Model Specification

Chga-CreERT2

Strain Name C57BL/6Smoc-Chgaem(CreERT2-Wpre-pA)Smoc
Catalog Number NM-KI-204993
Genetic Background C57BL/6Smoc
Gene Symbol Chga
Synonyms cgA, ChrA
NCBI ID 12652 ↗
MGI ID 88394 ↗
Ensembl ID ENSMUSG00000021194 ↗
Strain State Sperm cryopreservation
Research Application By mating the reporter mice with CreERT2-expressing mice, Chga positive cells derived from double-positive mice were permanently labeled by fluorescent protein after tamoxifen treatment. These mice may be useful in the research of hypertension, heart disease and enteritidis.

Validation Data

Chga-CreERT2-1.png

Fig. 1 Detection of tdTomato (red) in the pancreas of ChgaCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in the pancreas islet and some acinar cells can be induced by tamoxifen. 

Chga-CreERT2-3.png

Fig. 2 Detection of tdTomato (red) in various tissues of ChgaCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in some cells of the pancreas, lung, kidney and submandibular gland can be induced by tamoxifen. Some leakiness were detected in the brain, stomach, colon and intestine prior to tamoxifen exposure. Besides, tdtomato expression can not be detected in the liver, brown fat, spleen, muscle, skin, testis and epididymis. (For more detailed information please contact our technical advisor.)