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hAPOE3

Background : C57BL/6Smoc

Catalog : NM-HU-190003

Strain Name :

C57BL/6Smoc-Apoe^{tm3(hAPOE3)Smoc}

Gene Summary

Gene Name

Synonyms :
Apo-E, AI255918
NCBI ID :
11816
MGI ID :
88057
Ensembl ID :
ENSMUSG00000002985
Strain State :
活体

Model Description

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Validation Data

Validation data

Fig1. Genotyping of WT 、KO & Humanized mice by PCR.

Primer P1/2 Wild type = 342 bp

Primer P3/4 mutant = 332 bp

M：100bp Plus DNA ladder.

Fig2. Western blot analysis of APOE3 protein from WT、KO & Humanized mice.

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