hCD3E

Background : C57BL/6Smoc

Catalog : NM-HU-00114

Strain Name : C57BL/6Smoc-Cd3eem1(hCD3E) Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Cd3e gene was replaced by human CD3E gene . While hCD3E(2)(Stock No.NM-HU-210023) mice function similarly to hCD3E mice,for more detailed information please contact our technical advisor.

Validation Data

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Fig1. The expression of human CD3E in the peripheral blood cells derived from heterozygous or homozygous humanized mice was confirmed by FACS. 

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Fig2. Detection of T cell subsets in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

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Fig3. Detection of B and NK cells in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

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Fig4. In vitro T cell activation with heterozygous or homozygous CD3E humanized mice.

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Fig5. Cytokine analysis of anti-human CD3E antibody treated hCD3E mice. 

The data is provided by Crownbio.

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