hGCGR

Background : C57BL/6Smoc

Catalog : NM-HU-215004

Strain Name :

C57BL/6Smoc-Gcgrem(hGCGR)Smoc

Gene Summary

Gene Name

Model Description

The endogenous mice Gcgr gene was replaced by human GCGR gene.

Validation Data

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Fig1. Detection of GCGR expression in liver by RT-PCR. 

Wild type: only one band at 589 bp with primers F1/R1(mGcgr);

Homozygous: only one band at 501 bp with primers F2/R2(hGCGR).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png


Fig2. Detection of hGCGR expression in hGCGR Mice by WB. 

Abbr. M,marker; HO, homozygous; WT, wild type.

Note. The anti-human GCGR Antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig3. Detection of hGCGR expression in Kidney in hGCGR KI mice

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig4. Detection of hGCGR expression in Liver in hGCGR KI mice.

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.



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