Strain Model Specification

hMERTK

Strain Name C57BL/6Smoc-Mertktm1(hMERTK)/Smoc
Catalog Number NM-HU-2000031
Genetic Background C57BL/6Smoc
Gene Symbol Mertk
Synonyms Eyk, Mer, Nyk, nmf12
NCBI ID 17289 ↗
MGI ID 96965 ↗
Ensembl ID ENSMUSG00000014361 ↗
Strain State Repository Live
Research Application Immunotherapy,drug screening

Validation Data

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Fig1. Detection of MERTK expression by RT-PCR. 

Wild type: only one band at 201 bp with primers F2/R2(mMertk);

Homozygous: only one band at 122 bp with primers F1/R1(hMERTK); 

Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Human MERTK expression on lymph nodes is confirmed by Western Blot in the humanized MERTK mice. 

Human MERTK expresses on lymph nodes in the humanized MERTK mice.image.png

Fig3. Detection of hMerTK expression on human PBMC.

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Fig4. Detection of hMerTK expression on BMDM and BMDC in hMerTK KI mice. 

Abbr. BMDM, Bone Marrow Derived Macrophage; BMDC, Bone Marrow Derived Dendritic cell.

hMERTK-2.png

Fig5. Human MERTK expression on spleen cells is confirmed by immunofluorescence in the humanized MERTK mice. 

Human MERTK expresses obviously on spleen cells in the humanized MERTK mice.

hMERTK-3.png

Fig6. Human MERTK expression on thymus is confirmed by immunofluorescence in the humanized MERTK mice. 

Human MERTK expresses obviously on thymus in the humanized MERTK mice.