AI415265, AI747682, FH3, HCHOLA3, Narc1, PC9
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Fig1 Expression of PCSK9 in the serum of humanized PCSK9 homozygous mice is detected by Elisa. a The expression of human PCSK9 can be detected in the serum collected from homozygous mice . B The expression of mouse PCSK9 can not be detected in the serum collected from homozygous mice .
Fig2 Impact of evolocumab treatment on CHOL and LDL-C levels in humanized PCSK9 homozygous mice. A single intravenous injection of evolocumab reduced CHOL(a) and LDL-C(b) in humanized PCSK9 homozygous mice after 16 weeks of high-fat diet feeding. Average + SD; n = 6 to 7 mice per condition; *p<0.05, **p<0.01; (Student’s t test).
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