hSERPINC1

Background : C57BL/6Smoc

Catalog : NM-HU-225075

Strain Name : C57BL/6Smoc-Serpinc1tm1(hSERPINC1)Smoc

Gene Summary

Gene Name

Model Description

The endogenous mouse Serpinc1 gene was replaced by human SERPINC1 gene.

Validation Data

image.png

Fig1. Detection of SERPINC1 expression in liver by RT-PCR. 

Wild type: only one band at 250 bp with primers F1/R1 (mSerpinc1);

Homozygous: only one band at 374 bp with primers F2/R2 (hSERPINC1).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig2. Detection of hSERPINC1(A) and mSERPINC1(B) expression in serum by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig3. Detecion of coagulation time in hSERPINC1 knockin mice by APTT(n=3). 

Abbr. HO, homozygous; WT, wild type.



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