Siglec-G, Siglec10, mSiglec-G, 9830164H23, A630096C01Rik
胚胎冻存
Fig.1 Strain specific analysis of SIGLEC10 gene expression in WT and hSIGLEC10 mice by RT-PCR.
Mouse Siglecg mRNA was detectable in splenocytes of wild-type mice( P1/2 : 812bp). Human SIGLEC10 mRNA was detectable only in homozygous hSIGLEC10 mice (P3/2 : 394bp) , but not in the WT.
M：100bp Plus DNA ladder from Transgen (BM311)
Fig.2 Strain specific SIGLEC10 expression analysis in the CD19+ PBMC or splenocytes of homozygous hSIGLEC10 mice by FACS.
anti-mouse Siglec-G：BD Pharmingen™,563336；
anti-human Siglec-10：Biolegend，347603.
Fig.3 In vivo efficacy study in SIGLEC10 humanized mice grafted with MC38-hCD24 tumor model. CD24 mAb1 and CD24 mAb2 can inhibit the growth of MC38-hCD24 xenografts(A), and have no significant effect on the body weight of hSIGLEC10 mice (B).
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