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MHC Class II (I-A/I-E) -KO

Background : C57BL/6Smoc

Catalog : NM-KO-18032

Strain Name : C57BL/6Smoc-H2-Ab1^em1H2-Aa^em1 H2-Eb1^em1H2-Eb2^em1H2-Ea-ps^{em1 Smoc}

Gene Summary

Gene Name

Synonyms :
Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-Ab, I-Abeta, Rmcs1, Aalpha, A alpha, H-2Aa, Ia1, Ia-1, I-Aalpha, H-2Eb, Ia4, Ia-4, A130038H09Rik, H-2Eb2, Ia5, Ia-5, H-2Ea, Ia3, Ia-3, I-Ealpha
NCBI ID :
14961 14960 14969 381091 100504404
MGI ID :
103070 95895 95901 95902 95900
Ensembl ID :
ENSMUSG00000073421 ENSMUSG00000036594 ENSMUSG00000060586 ENSMUSG00000067341 ENSMUSG00000036322
Strain State :
胚胎冻存

Model Description

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

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