Mnx1-IRES-Cre

Background : C57BL/6Smoc

Catalog : NM-KI-200010

Strain Name : C57BL/6Smoc-Mnx1em1(IRES-Cre-WPRE-polyA)Smoc

Gene Summary

Gene Name

Model Description

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Mnx1 gene stop codon site. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Mnx1. These mice may be useful for studying spinal muscular atrophy (SMA).

Validation Data

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Fig. 1 Cre-mediated recombination in the spinal cord of Mnx1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the spinal cord of Mnx1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Mnx1Cre/+; Rosa26tdTomato/+ mice. Tdtomato expression can be detected in the brain, kidney, intestine, colon, eyes, ovary, salivary gland, stomach, liver, skin, heart, lung, pituitary gland, muscle, spleen, brown fat and thymus. (For more detailed information please contact our technical advisor.)


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