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Home / Toolbox of Mice / Find Cre / Ntrk2-CreERT2

Ntrk2-CreERT2

Background : C57BL/6Smoc

Catalog : NM-KI-200146

Strain Name : C57BL/6Smoc-Ntrk2em1(CreERT2-WPRE-polyA)Smoc

Gene Summary

Gene Name
  • Synonyms :

    Tkrb, trkB, trk-B, GP145-TrkB/GP95-TrkB

  • NCBI ID :

    18212

  • MGI ID :

    97384

  • Ensembl ID :

    ENSMUSG00000055254

  • Strain State :

    精子冻存

Model Description

A CreERT2-WPRE-polyA expression cassette was knocked into the Ntrk2 gene start codon site. Ntrk2 encodes the tropomyosin receptor kinase B (TrkB), transmission through which neurotrophic factors modify differentiation, plasticity, and synaptic transmission. When these Ntrk2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Ntrk2 expressing cells.

Validation Data

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Fig. 1 CreERT2-mediated recombination in the multiple brain regions of Ntrk2-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 2 CreERT2-mediated recombination in individual cells in the lungs of Ntrk2-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

image.png

Fig. 3 Tdtomato was also abundantly expressed in brown fat, and expressed in thymus, salivary gland, spleen, large intestine, stomach and skin. There was a small amount of expression in kidney, and no expression in the heart, small intestine and muscle.（For more information please contact: 400-728-0660.）



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