Tumor Targets

Humanized tumor target mice are immunocompetent chimeric mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigen, etc. These models can can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drug.

Immune Checkpoints

GenoBioTX has developed a set of mouse models expressing humanized immune checkpoints. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice.

Complements

GenoBioTX has developed a set of mouse models expressing humanized complements. These models are suitable to assess the efficacy of drugs targeting complements in fully immunocompetent mice.

Cytokines

GenoBioTX has developed a set of mouse models expressing humanized cytokines. These models are suitable to assess the efficacy of drugs targeting cytokines in fully immunocompetent mice.

Metabolic Targets

GenoBioTX has developed a set of mouse models expressing humanized metabolic targets. These models are suitable to assess the efficacy of drugs targeting metabolic pathways proteins in fully immunocompetent mice.

Viral Infection Receptors

Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. The construction of humanized viral infection receptor knockin mice will greatly facilitated researchers’ abilities to study host responses to viral infections in a cost effective and ethical manner.

Other Targets