Immune-Related Mice

Mice with defective adaptive immunity including nude, SCID and NOD-SCID mice, can effectively control common opportunistic agents such as Pseudomonas spp., until myeloablative effects from irradiation or other interventions eliminate their innate immunity as well. The effects of ionizing radiation on other tissues, and on developing or proliferating cells, influence morbidity and mortality of research mice.

Target Classifications

Immunodeficient

Humanized Drug Targets

Cytokine Reporters

Inducible Cell Ablation

Cell-specific Reporter

Cytokine Reporters

Cytokines are a large, diverse family of small proteins or glycoproteins. Cytokine reporter mouse models express marker molecules under the control of elements from cytokine genes that enable easy identification of their cellular sources. Such systems are well-accepted tools for research of cytokine function.