Genetically Edited Rats Archives

Genetically Edited Rats

Genetically engineered mice and rats are animals that have had their genomes altered through the use of genetic engineering techniques to more precisely model human phenotypes and pathologies, giving researchers a better way to explore mechanisms and greater confidence in the translational potential of their findings.

Target Classifications

Reporters

Rat models carrying knock-in or transgenic fluorescent reporter genes for gene expression profiling and visual analysis, protein subcellular localization, and genetic lineage tracing.

Cre-drivers

Including: Cre recombinase, reporter gene, and Cas9-related rat

Immunodeficient

Immunodeficient rat models for xenografting (PDX, CDX), and cancer and cancer stem cell studies (ES/iPS), hematopoietic and immunological studies, and pharmacodynamic studies.

Humanized Drug Targets

Humanized rats of drug target genes, such as humanized rats of immune checkpoint genes, for drug screening and drug efficacy evaluation, helping accelerate the development of drugs.

Diseases

Rat models of human diseases for studying the role of genes in the inheritance, pathogenesis and progression of diseases.

Reporters

Rat models carrying knock-in or transgenic fluorescent reporter genes for gene expression profiling and visual analysis, protein subcellular localization, and genetic lineage tracing.