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Humanized Models

Therapeutic Targeted Humanized Models: Advancing Biomedical Research

Welcome to GenoBioTX, where cutting-edge innovation meets groundbreaking research in the field of therapeutic targeted animal models. Our advanced genetically modified mice are at the forefront of biomedical research, providing unparalleled insights into human diseases and therapeutic strategies.

Introduction to Therapeutic Targeted Humanized Models

Humanized mouse models are experimental animals that have been genetically modified or implanted with human cells, tissues, or genes. These models are used in biomedical research to study human diseases, test therapies, and understand biological processes. By incorporating human biological components into mice, researchers can investigate how diseases develop, how the immune system responds to treatments, and how drugs interact with human cells in a controlled laboratory setting. Humanized mouse models are valuable tools for advancing medical research and drug development, providing insights that can potentially lead to new treatments and therapies for human diseases.

Target Classifications

Tumor Targets

Humanized tumor target mice are immunocompetent chimeric mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigen, etc. These models can can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drug.

Immune Checkpoints

GenoBioTX has developed a set of mouse models expressing humanized immune checkpoints. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice.

Complements

GenoBioTX has developed a set of mouse models expressing humanized complements. These models are suitable to assess the efficacy of drugs targeting complements in fully immunocompetent mice.

Cytokines

GenoBioTX has developed a set of mouse models expressing humanized cytokines. These models are suitable to assess the efficacy of drugs targeting cytokines in fully immunocompetent mice.

Cytokine Receptors

GenoBioTX has developed a set of mouse models expressing humanized cytokines receptors. These models are suitable to assess the efficacy of drugs targeting cytokines receptors in fully immunocompetent mice.

Metabolic Targets

GenoBioTX has developed a set of mouse models expressing humanized metabolic targets. These models are suitable to assess the efficacy of drugs targeting metabolic pathways proteins in fully immunocompetent mice.

Viral Infection Receptors

Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. The construction of humanized viral infection receptor knockin mice will greatly facilitated researchers’ abilities to study host responses to viral infections in a cost effective and ethical manner.