Immune-Related Mice Archives

Immune-Related Mice

Mice with defective adaptive immunity including nude, scid and NOD scid mice can effectively control common opportunistic agents such as Pseudomonads, until myeloablative effects of irradiation or other interventions eliminate their innate immunity as well. 185 Effects of ionizing radiation on other tissues, and on developing or proliferating cells, influence morbidity and mortality of research mice.

Target Classifications

Immunodeficient

Immunodeficient mice are specialized laboratory models that lack specific components of their immune system, making them invaluable for studying human diseases and testing therapeutic interventions. These mice can be readily applied for PK/PD assays, reconstitution of a humane immune system, CDX/PDX model construction, disease research, drug efficacy evaluation and more.

Humanized Drug Targets

Humanized mice of drug target genes, such as humanized mice of immune checkpoint genes, for drug screening and drug efficacy evaluation, helping accelerate the development of drugs.

Cytokine Reporters

Cytokines are a large, diverse family of small proteins or glycoproteins. Cytokine reporter mouse models express marker molecules under the control of elements from cytokine genes that enable easy identification of their cellular sources. Such systems are well-accepted tools for research of cytokine function.

Inducible Cell Ablation

Inducible cell ablation mouse models express DTR molecules under the control of elements from cell-specific genes. The targeted cells will be deleted after diphtheria toxin (DT) treatment. Such systems enable the studies of the function of immune cells.

Cell-specific Reporter

Cell-specific Reporter mouse models express marker molecules under the control of elements from cell-specific genes that enable the studies of live cell imaging, cell lineage tracing, etc.